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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS39 All Species: 34.24
Human Site: T614 Identified Species: 62.78
UniProt: Q96JC1 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96JC1 NP_056104.2 886 101809 T614 I I H V W E E T G S R F H N C
Chimpanzee Pan troglodytes XP_510331 886 101752 T614 I I H V W E E T G S R F H N C
Rhesus Macaque Macaca mulatta XP_001102792 886 101693 T614 I I H V W E E T G A R F H N C
Dog Lupus familis XP_849407 886 101720 T614 V I H V W E E T G S R F H N C
Cat Felis silvestris
Mouse Mus musculus Q8R5L3 886 101674 T614 I I H V W E E T G S Q F H N C
Rat Rattus norvegicus XP_001075756 886 101629 T614 I I H V W E E T G T R F H N C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518189 1309 145152 T1037 V I H V W E E T G A D F H N R
Chicken Gallus gallus NP_001026365 875 100503 T603 I I H V W E E T G A H F H N C
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A4IG72 863 97029 Q604 L V L E K K L Q K E K Y H T H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650702 876 100146 G616 V I T E W K D G N T L L H N V
Honey Bee Apis mellifera XP_392710 866 100055 T610 V V H V W E D T N L L F H N V
Nematode Worm Caenorhab. elegans NP_001041163 923 104932 P629 V I F K W E E P S S Y F H E T
Sea Urchin Strong. purpuratus XP_798217 824 94304 E607 I I L N C S D E T P E F H N R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.3 98 N.A. 97.4 96.8 N.A. 59.2 92.7 N.A. 26.4 N.A. 35.4 42.4 31.7 51.5
Protein Similarity: 100 99.8 99.7 99.3 N.A. 98.9 98.5 N.A. 62.8 96.1 N.A. 46.8 N.A. 55.6 62 52.5 68.4
P-Site Identity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. 73.3 86.6 N.A. 6.6 N.A. 26.6 53.3 46.6 33.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 86.6 93.3 N.A. 40 N.A. 53.3 73.3 53.3 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 54 % C
% Asp: 0 0 0 0 0 0 24 0 0 0 8 0 0 0 0 % D
% Glu: 0 0 0 16 0 77 70 8 0 8 8 0 0 8 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 85 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 62 0 0 0 0 0 0 % G
% His: 0 0 70 0 0 0 0 0 0 0 8 0 100 0 8 % H
% Ile: 54 85 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 8 8 16 0 0 8 0 8 0 0 0 0 % K
% Leu: 8 0 16 0 0 0 8 0 0 8 16 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 16 0 0 0 0 85 0 % N
% Pro: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 39 0 0 0 16 % R
% Ser: 0 0 0 0 0 8 0 0 8 39 0 0 0 0 0 % S
% Thr: 0 0 8 0 0 0 0 70 8 16 0 0 0 8 8 % T
% Val: 39 16 0 70 0 0 0 0 0 0 0 0 0 0 16 % V
% Trp: 0 0 0 0 85 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _